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This Article Full Text Full Text (PDF) All Versions of this Article: 90/4/487    most recent expphysiol.2005.029835v1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Vignaud, A Articles by Ferry, A Search for Related Content PubMed PubMed Citation Articles by Vignaud, A Articles by Ferry, A Related Collections Muscle

¹ Laboratoire d'étude de la croissance cellulaire, régénération et réparation tissulaires, FRE 2412 CNRS, Université Paris 12, Créteil, France ² Université Paris 5, Paris, France

Non-steroidal anti-inflammatory drugs are frequently prescribed after skeletal muscle injury. It is not known whether this type of medication can interfere with muscle repair, although inflammatory response is thought to play an important role in this process. Tibialis anterior muscles of mice were injured by myotoxic agent (snake venom) or crushed. Then, animals were treated daily for 10–14 days with different types of non-steroidal anti-inflammatory and antioxidant drugs. The long-term repair was studied 10–42 days after injury by analysing the recovery of in situ muscle force production, size of regenerating muscle cells and expression of myosin heavy chain. Our results show that diclofenac, diferuloylmethane (curcumin), dimethylthiourea or pyrrolidine dithiocarbamate treatment did not significantly affect muscle recovery after myotoxic injury (P > 0.05). Similarly, diferuloylmethane, dimethyl sulphoxide or indomethacin administration did not markedly change muscle repair after crush injury. However, we noted that high doses (> 2 mg kg^–1) of diferuloylmethane or indomethacin increased lethality and reduced muscle repair after crush injury. In conclusion, non-steroidal anti-inflammatory and antioxidant drugs did not exhibit long-term detrimental effects on muscle recovery after injury, except at lethal doses.

(Received 6 January 2005; accepted after revision 21 February 2005; first published online 22 February 2005)
Corresponding author A. Ferry: Laboratoire d'étude de la croissance cellulaire, régénération et réparation tissulaires, UMR 7149 CNRS, Université Paris 12, Créteil, France. Email: ferry{at}univ-paris12.fr