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This Article Full Text Full Text (PDF) All Versions of this Article: 90/4/653    most recent expphysiol.2005.030197v1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Rabon-Stith, K. M Articles by Hurley, B. F Search for Related Content PubMed PubMed Citation Articles by Rabon-Stith, K. M Articles by Hurley, B. F Related Collections Human, Environmental & Exercise

¹ Department of Kinesiology, University of Maryland, College Park, MD 20742, USA ² Division of Gerontology and Geriatric Research, Education, and Clinical Center, School of Medicine, University of Maryland, Baltimore, MD 21244, USA ³ Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15238, USA ⁴ Diet and Human Performance Laboratory, United States Department of Agriculture, Beltsville, MD 20705, USA

To determine the influence of the vitamin D receptor (VDR) gene FokI and BsmI genotype on bone mineral density response to two exercise training modalities, 206 healthy men and women (50–81 years old) were studied before and after 5–6 months of either aerobic exercise training (AT) or strength training (ST). A totla of 123 subjects completed AT (51 men, 72 women) and 83 subjects completed ST (40 men, 43 women). DNA was extracted from blood samples of all subjects and genotyping was performed at the VDR FokI and BsmI locus to determine its association to training response. Total body, greater trochanter and femoral neck bone mineral density (BMD) were measured before and after both training programmes using dual-energy X-ray absorptiometry. VDR BsmI genotype was not significantly related to BMD at baseline or after ST or AT. However, VDR FokI genotype was significantly related to ST- but not AT-induced changes in femoral neck BMD (P < 0.05). The heterozygotes (Ff) in the ST group approached a significantly greater increase in femoral neck BMD (P = 0.058) compared to f homozygotes. There were no significant genotype relationships in the AT group. These data indicate that VDR FokI genotype may influence femoral neck BMD response to ST, but not AT.

(Received 31 January 2005; accepted after revision 5 May 2005; first published online 12 May 2005)
Corresponding author K. M. Rabon-Stith: Department of Kinesiology, University of Maryland, College Park, MD 20742, USA. Email: kstith{at}umd.edu

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