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Hot Topic Review |
1 Hammersmith Campus, Imperial College, Du Cane Road, London W12 0NN, UK
Abstract
Hypoxia-inducible factor (HIF) is a transcription complex which responds to changes in oxygen, providing cells with a master regulator that coordinates changes in gene transcription. HIF operates in all mammalian cell types and is ancient in evolutionary terms, being conserved in C. elegans and D. melanogaster. This review summarizes recent insights into the molecular events that link reduced oxygenation to HIF activation and emerging insights into the extensive role of HIF in a broad range of physiological processes.
(Received 8 August 2005;
accepted after revision 7 September 2005; first published online 12 September 2005)
Corresponding author P. H. Maxwell: Hammersmith Campus, Imperial College, Du Cane Road, London W12 0NN, UK. Email: p.maxwell{at}imperial.ac.uk
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