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This Article Full Text Full Text (PDF) All Versions of this Article: 90/6/855    most recent expphysiol.2005.030858v1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kruszewska, D. Articles by Pierzynowski, S. G Search for Related Content PubMed PubMed Citation Articles by Kruszewska, D. Articles by Pierzynowski, S. G Related Collections GI & Epithelial

Danuta Kruszewska¹, Pawe Podgurniak², Åsa Ljungh¹, Aleksandra Sebastian¹, Lennart Larsson¹, Jolanta Zajdel-Dbrowska³ and Stefan G Pierzynowski⁴⁵

¹ Department of Laboratory Medicine, Lund University, Sölvegatan 23, SE-223 62 Lund, Sweden ² Department of Physiological Sciences, Warsaw Agricultural University, Nowoursynowska 159, 02-787 Warsaw, Poland ³ Department of Pharmaceutical Microbiology, Medical University, Oczki 3, 02-007 Warsaw, Poland ⁴ Department of Cell and Organism Biology, Lund University, Helgonavägen 3b, SE-223 62 Lund, Sweden ⁵ Sea Fisheries Institute, Kotaja 1, 81-332 Gdynia, Poland

The effect of extremely low electrical currents, identical to those generated by the gut smooth muscle, on bacterial autolysin production in vitro was tested in the present study. When stimulated with these electrical currents, the bacteria Pediococcus pentosaceus 16:1 produced groups of peptidoglycan hydrolases that differed from those produced by the unstimulated (control) bacteria. The autolysins synthesized by the P. pentosaceus 16:1 under extremely low electrical currents were effective against peptidoglycans from the cell walls of various lactic acid bacteria strains, whereas the autolysins from the control bacteria acted exclusively against P. pentosaceus 16:1 cell walls. Thus, it can be predicted that in vivo the electrical currents generated by the intestinal smooth muscles, which can be recorded as the myoelectrical migrating complexes, could regulate lactic acid bacteria strain growth in the gut.

(Received 8 May 2005; accepted after revision 12 August 2005; first published online 23 August 2005)
Corresponding author : S. G. Pierzynowski: Department of Cell and Organism Biology, Lund University, Helgonavägen 3b, SE-223 62 Lund, Sweden. Email: stefan.pierzynowski{at}telia.com

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