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This Article Full Text Full Text (PDF) All Versions of this Article: 90/6/881    most recent expphysiol.2005.030718v1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Kulaputana, O. Articles by Hagberg, J. M Search for Related Content PubMed PubMed Citation Articles by Kulaputana, O. Articles by Hagberg, J. M

¹ Department of Kinesiology, University of Maryland, College Park, MD 20742, USA ² Department of Neurology, University of Maryland School of Medicine, Baltimore, MD 21201, USA ³ Geriatric Research, Education, and Clinical Center, Baltimore VA Medical Center, Baltimore, MD 21201, USA ⁴ Division of Gerontology, University of Maryland School of Medicine, Baltimore, MD 21201, USA

Endurance exercise training improves fibrinolysis, but this training-induced adaptation may differ somewhat between men and women. We sought to determine whether the potential gender differences in training-induced changes in selected fibrinolysis measures were related to changes in adiposity and/or plasma lipoprotein lipid levels. Seventeen men and 28 women, 50–75 years old, who were generally overweight to obese, were assessed for plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (t-PA) activity, t-PA antigen and plasma lipoprotein-lipid levels, and body composition before and after 6 months of endurance exercise training while on a low-fat diet. At baseline, there were no differences in fibrinolytic measures between the men and women. Baseline levels of these fibrinolytic markers in both men and women were primarily related to other fibrinolytic measures and body composition, with a smaller contribution from plasma high-density lipoprotein cholesterol (HDL-C) levels. Exercise training reduced t-PA antigen levels in both men and women, but the reduction was significantly greater in men (–1.6 ± 0.3 versus –0.5 ± 0.2 ng ml^–1, P = 0.007). Exercise training decreased PAI-1 activity more in men than in women (–2.6 ± 1.4 versus +0.9 ± 0.9 IU ml^–1, P = 0.03). Men and women both showed increased t-PA activity with exercise training to the same extent (+0.38 ± 0.12 versus +0.36 ± 0.24 U ml^–1). The changes in fibrinolytic measures with exercise training in men and women were correlated with changes in other fibrinolytic measures, although in men abdominal fat changes were a strong predictor of fibrinolytic changes with training. These findings suggest that training-induced improvements in endogenous fibrinolysis markers are somewhat greater in men compared to women and may be more strongly associated with abdominal obesity in men.

(Received 26 April 2005; accepted after revision 22 August 2005; first published online 23 August 2005)
Corresponding author J. Hagberg: Department of Kinesiology, University of Maryland, College Park, MD 20742–2611, USA. Email: hagberg{at}umd.edu