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Themed Issue Papers |
1 Graduate School of Engineering Science2 School of Health and Sport Sciences, Osaka University, Toyonaka, Japan 3 Institute of Health Science, Kyushu University, Kasuga, Japan
We investigated the role played by the exercise pressor reflex in sympathetic regulation of the renal circulation in rats. In mid-collicular decerebrate rats, mean arterial pressure (MAP), heart rate (HR), left renal cortical blood flow (RCBF) and left renal sympathetic nerve activity (RSNA) were recorded before and during 30 s of static contraction of the left triceps surae muscles evoked by electrical stimulation of the tibial nerve, which activates both metabo- and mechanosensitive muscle afferents, and during 30 s of passive stretch of the left Achilles tendon, which selectively activates mechanosensitive muscle afferents. Static contraction (n = 17, +344 ± 34 g developed tension) significantly (P < 0.05) increased MAP (+14 ± 3 mmHg), HR (+6 ± 1 beats min–1) and RSNA (n = 11, +19 ± 5%) and significantly decreased renal cortical vascular conductance (RCVC, n = 11, –11 ± 2%). Passive stretch (n = 20, +378 ± 11 g) also significantly increased MAP (+11 ± 2 mmHg), HR (+7 ± 2 beats min–1) and RSNA (n = 15, +14 ± 4%) and significantly decreased RCVC (n = 11, –12 ± 3%). RCBF showed no significant changes during static contraction or passive stretch. Renal denervation abolished the decrease in RCVC during contraction (n = 12) or stretch (n = 13). These data indicate that both the exercise pressor reflex and its mechanically sensitive component, the muscle mechanoreflex, induced renal cortical vasoconstriction through sympathetic activation in rats.
(Received 27 July 2005;
accepted after revision 4 October 2005; first published online 6 October 2005)
Corresponding author N. Hayashi: Institute of Health Science, Kyushu University, 6-1 Kasuga-Kouen, Kasuga, Fukuoka, 816-8580, Japan. Email: naohayashi{at}ihs.kyushu-u.ac.jp
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