Experimental Physiology Celebrating 100 years
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Experimental Physiology 91.2 pp 307-321
DOI: 10.1113/expphysiol.2005.031062
© The Physiological Society 2006
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
91/2/307    most recent
expphysiol.2005.031062v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kohl, P.
Right arrow Articles by Garny, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kohl, P.
Right arrow Articles by Garny, A.
Related Collections
Right arrow Heart/Cardiac Muscle

Themed Issue Papers

Modelling of Biological Systems

Effects of mechanosensitive ion channels on ventricular electrophysiology: experimental and theoretical models

Peter Kohl1, Christian Bollensdorff1 and Alan Garny1

1 The Cardiac Mechano-Electric Feedback Group, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK

The heart is an electrically driven mechanical pump, somewhat like an electric motor. Interestingly, like an electric motor in ‘dynamo mode’, the heart can also convert mechanical stimuli into electrical signals. This feedback from cardiac mechanics to electrical activity involves mechanosensitive ion channels, whose properties and pathophysiological relevance are reviewed in the context of experimental and theoretical modelling of ventricular beat-by-beat electromechanical function.

(Received 13 October 2005; accepted after revision 10 January 2006; first published online 11 January 2006)
Corresponding author P. Kohl: The Cardiac Mechano-Electric Feedback Group, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK. Email: peter.kohl{at}physiol.ox.ac.uk




This article has been cited by other articles:


Home page
 Brief BioinformHome page
P. J. Hunter, E. J. Crampin, and P. M. F. Nielsen
Bioinformatics, multiscale modeling and the IUPS Physiome Project
Brief Bioinform, July 1, 2008; 9(4): 333 - 343.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
M. E. Mangoni and J. Nargeot
Genesis and Regulation of the Heart Automaticity
Physiol Rev, July 1, 2008; 88(3): 919 - 982.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
E. Kizana, C. Y. Chang, E. Cingolani, G. A. Ramirez-Correa, R. B. Sekar, M. R. Abraham, S. L. Ginn, L. Tung, I. E. Alexander, and E. Marban
Gene Transfer of Connexin43 Mutants Attenuates Coupling in Cardiomyocytes: Novel Basis for Modulation of Cardiac Conduction by Gene Therapy
Circ. Res., June 8, 2007; 100(11): 1597 - 1604.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
G. Iribe, M. Helmes, and P. Kohl
Force-length relations in isolated intact cardiomyocytes subjected to dynamic changes in mechanical load
Am J Physiol Heart Circ Physiol, March 1, 2007; 292(3): H1487 - H1497.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
P. Hunter
Modelling of biological systems themed issue.
Exp Physiol, March 1, 2006; 91(2): 283 - 284.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2006 by the The Physiological Society.