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This Article Full Text Full Text (PDF) All Versions of this Article: 91/2/383    most recent expphysiol.2005.031021v1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Buist, M. L. Articles by Pullan, A. J. Search for Related Content PubMed PubMed Citation Articles by Buist, M. L. Articles by Pullan, A. J. Related Collections GI & Epithelial

¹ National University of Singapore, Singapore² Bioengineering Institute⁴ Department of Engineering Science, The University of Auckland, New Zealand³ Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, USA

During recent years there has been a growing interest in the assessment of gastric electrical health through cutaneous abdominal recordings. The analysis of such recordings is largely limited to an inspection of frequency dynamics, and this has raised doubts as to whether functional gastric electrical uncoupling can be detected using this technique. We describe here a computational approach to the problem in which the equations governing the underlying physics of the problem have been solved over an anatomically detailed human torso geometry. Cellular electrical activity was embedded within a stomach tissue model, and this was coupled to the torso using an equivalent current source approach. Simulations were performed in which normal and functionally uncoupled (through the introduction of an ectopic antral pacemaker) gastric slow wave activity was present, and corresponding cutaneous electrogastrograms were produced. These were subsequently analysed using the currently recommended techniques, and it was found that the functionally uncoupled situation was indistinguishable from normal slow wave activity using this approach.

(Received 30 October 2005; accepted after revision 6 January 2006; first published online 11 January 2006)
Corresponding author M. L. Buist: Division of Bioengineering, National University of Singapore 117576. Email: biebml{at}nus.edu.sg

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