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This Article Full Text Full Text (PDF) All Versions of this Article: 91/4/765    most recent expphysiol.2006.033357v1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Vogelsang, T. W. Articles by Volianitis, S. Search for Related Content PubMed PubMed Citation Articles by Vogelsang, T. W. Articles by Volianitis, S. Related Collections Cardiovascular control

¹ The Copenhagen Muscle Research Centre, Departments of Anaesthesia, Nuclear Medicine & PET, Rigshospitalet, Copenhagen, Denmark² The Copenhagen Muscle Research Centre, Departments of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, Copenhagen, Denmark ³ Department of Medical Physiology, The Panum Institute, University of Copenhagen, Denmark ⁴ School of Sport and Education, Brunel University, Middlesex, UK

During arm exercise (A), mean arterial pressure (MAP) is higher than during leg exercise (L). We evaluated the effect of central blood volume on the MAP response to exercise by determining plasma atrial natriuretic peptide (ANP) during moderate upright and supine A, L and combined arm and leg exercise (A + L) in 11 male subjects. In the upright position, MAP was higher during A than at rest (102 ± 6 versus 89 ± 6 mmHg; mean ± S.D.) and during L (95 ± 7 mmHg; P < 0.05), but similar to that during A + L (100 ± 6 mmHg). There was no significant change in plasma ANP during A, while plasma ANP was higher during L and A + L (42.7 ± 12.2 and 43.3 ± 17.1 pg ml^–1, respectively) than at rest (34.6 ± 14.3 pg ml^–1, P < 0.001). In the supine position, MAP was also higher during A than at rest (100 ± 7 versus 86 ± 5 mmHg) and during L (92 ± 5 mmHg; P < 0.01) but similar to that during A + L (102 ± 6 mmHg). During supine A, plasma ANP was higher than at rest and during L but lower than during A + L (73.1 ± 22.5 versus 47.2 ± 15.9, 67.4 ± 18.3 and 78.1 ± 25.0 pg ml^–1, respectively; P < 0.05). Thus, upright A was the exercise mode that did not enhance plasma ANP, suggesting that central blood volume did not increase. The results suggest that the similar blood pressure response to A and to A + L may relate to the enhanced central blood volume following the addition of leg to arm exercise.

(Received 27 January 2006; accepted after revision 27 April 2006; first published online 4 May 2006)
Corresponding author S. Volianitis: Department of Anaesthesia, AN 2041, Rigshospitalet, Blegdamsvej 9, Copenhagen Ø, 2100 Denmark. Email: stefanos.volianitis{at}excite.com