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This Article Full Text Full Text (PDF) All Versions of this Article: 92/2/399    most recent expphysiol.2006.035253v1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Kiciak, A. Articles by Bielecki, K. Search for Related Content PubMed PubMed Citation Articles by Kiciak, A. Articles by Bielecki, K.

Adam Kiciak^1,2, Jarosaw Woliñski², Katarzyna Borycka¹, Romuald Zabielski³ and Krzysztof Bielecki^1,2

¹ Department of General and Gastrointestinal Surgery, Medical Centre of Postgraduate Education, Orlowski Hospital, Warsaw, Poland ² The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Jabonna, Poland ³ Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw Agricultural University, Warsaw, Poland

We designed a conscious pig model to investigate myoelectric activity and the number of interstitial cells of Cajal (ICC) in the proximal jejunum following the Roux-en-Y and ‘uncut’ Roux procedures in relation to clinical outcomes. Twelve male Polish White pigs (8 weeks old, 10–13 kg) underwent surgery under general anaesthesia first to implant bipolar electrodes and telemetry transmitters for continuous electromyography recordings and then, after 1 week recovery, to create Roux-en-Y (n = 6) and ‘uncut’ Roux loops (n = 6). Upper gut tissue specimens were studied for the expression of c-kit staining procedure to quantitatively identify the presence of interstitial cells of Cajal. The intestinal migrating motor complex was restored within 10.5 and 37 h in ‘uncut’ Roux and Roux-en-Y pigs, respectively (P < 0.05). During 2 weeks, the ‘uncut’ Roux piglets increased their body weight by 18.0%, whereas the Roux-en-Y piglets increased their body weight by only 7.3% (P 0.05). Two weeks after surgery, the number of ICC located in the region of Auerbach's plexus was higher and adhesions in the abdominal cavity lower in the ‘uncut’ Roux group. In conclusion, in the pig model, preservation of smooth muscle and ICC network continuity in the proximal jejunum may play an important role in early postsurgical recovery.

(Received 23 July 2006; accepted after revision 8 December 2006; first published online 14 December 2006)
Corresponding author A. Kiciak: Department of General Surgery and Gastroenterology, Medical Centre of Postgraduate Education, Orlowski Hospital, 231 Czerniakowska Street, 00-416 Warsaw, Poland. Email: adamkic{at}yahoo.com