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Experimental Physiology 92.4 pp 671-676
DOI: 10.1113/expphysiol.2007.037457
© The Physiological Society 2007
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Autonomic Neuroscience

Activation of paraventricular nucleus neurones by the dorsomedial hypothalamus via a tachykinin pathway in rats

 Matthew D. Womack1 and Richard Barrett-Jolley1

1 Department of Veterinary Preclinical Sciences, Veterinary Sciences Building, Brownlow Hill & Crown Street, University of Liverpool, Liverpool L69 7ZJ, UK

The dorsomedial hypothalamus (DMH) innervates the paraventricular nucleus (PVN) with substance P (SP) immunoreactive neurones. The PVN itself powerfully influences both the neuroendocrine and the cardiovascular systems. In this in vitro study, we examine the DMH-to-PVN pathway electrophysiologically. Glutamate application to the DMH increased action current frequency in the PVN. This effect was prevented by the glutamate antagonist kynurenic acid or by synaptic block with a high-Mg2+ low-Ca2+ buffer solution. Crucially, the selective tachykinin NK1 receptor antagonist L-703606 also inhibited DMH-to-PVN neurotransmission. Thus we show, for the first time, an excitatory connection between the DMH and PVN that uses tachykinin NK1 receptors. This pathway may be important for the hypothalamic control of neuroendocrine and/or cardiovascular function.

(Received 21 February 2007; accepted after revision 10 April 2007; first published online 27 April 2007)
Corresponding author R. Barrett-Jolley: Department of Veterinary Preclinical Sciences, Veterinary Sciences Building, Brownlow Hill & Crown Street, University of Liverpool, Liverpool L69 7ZJ, UK. Email: rbj{at}liverpool.ac.uk

Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial explotation.






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