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Experimental Physiology 92.5 pp 801-806
DOI: 10.1113/expphysiol.2007.036236
© The Physiological Society 2007
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Symposium Reports

Molecular transduction mechanisms of cytokine–hormone interactions: role of gp130 cytokines

 Juan Gerez1, José Bonfiglio1, Sebastian Sosa1, Damiana Giacomini1, Matias Acuña1, Alberto Carbia Nagashima1, Marcelo J. Perone1, Susana Silberstein1, Ulrich Renner2, Günter K. Stalla2 and Eduardo Arzt1

1 Laboratorio de Fisiología y Biología Molecular, Departamento de Fisiología y Biología Molecular y Celular, FCEN, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina 2 Max Planck Institute of Psychiatry, 80804 Munich, Germany

Abstract

Highly sophisticated mechanisms confer on the immune system the capacity to respond with a certain degree of autonomy. However, the final outcome of an immune response depends on the interaction of the immune system with other systems. The immune and neuroendocrine systems have an intimate cross-communication that makes possible a satisfactory response to environmental changes. Part of this interaction occurs through cytokines and steroid hormones. The last step of this cross-talk is the molecular level. As a model of interaction, this review focuses on the gp130 cytokine family. These cytokines, as well as their receptors, are expressed in pituitary cells. They regulate hormone production as well as growth of pituitary cells. During acute or chronic inflammation or infection, systemic, hypothalamic and hypophyseal gp130 cytokines act on anterior pituitary cells, integrating the neuroendocrine–immune response. Disruptions of these pathways may lead not only to abnormal growth of pituitary cells but also to immune disorders, for which, based on recent findings, targeting these cytokines might be a novel therapeutic approach.

(Received 9 May 2007; accepted after revision 22 June 2007; first published online 24 August 2007)
Corresponding author E. Arzt: Laboratorio de Fisiología y Biología Molecular, FCEN, UBA, Ciudad Universitaria, 1428 Buenos Aires, Argentina. Email: earzt{at}fbmc.fcen.uba.ar




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Neuroimmune interactions
Exp Physiol, September 1, 2007; 92(5): 799 - 800.
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