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This Article Full Text Full Text (PDF) All Versions of this Article: 92/5/945    most recent expphysiol.2007.037135v1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hodyc, D. Articles by Herget, J. Search for Related Content PubMed PubMed Citation Articles by Hodyc, D. Articles by Herget, J.

Daniel Hodyc¹, Michal norek¹, Tomá Brtnick¹ and Jan Herget¹

¹ Department of Physiology, Charles University in Prague, Second Medical School, Prague, Czech Republic

Hypoxic pulmonary vasoconstriction (HPV), an important physiological mechanism, is regulated by changes in the production of and interactions among reactive oxygen species (ROS). There is controversy, however, over whether HPV is mediated by an increase or a decrease in ROS production. Also, the role of NO in HPV remains unclear. The aim of this study was to investigate whether the inhibition of HPV by the antioxidant tempol was dependent on the concentration of NO, and how its effect was influenced by increased basal pulmonary vascular tone. In isolated rat lungs, we measured vasoconstrictor responses to acute ventilatory hypoxia before and after administration of tempol during perfusion with or without L-NAME. We found that tempol abolished HPV independently of NO production. When we increased basal vascular tone by K⁺-induced depolarization, we also found that tempol completely inhibited HPV. Our results indicate that inhibition of HPV by the superoxide dismutase mimetic tempol does not depend on either NO production or a decrease in basal vascular tone.

(Received 25 January 2007; accepted after revision 8 May 2007; first published online 11 May 2007)
Corresponding author D. Hodyc: Department of Physiology, Charles University, Second Medical School, Plzenska 130/221, 150 00 Prague 5, Czech Republic. Email: daniel.hodyc{at}lfmotol.cuni.cz

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				J. P. T. Ward Curiouser and curiouser: the perplexing conundrum of reactive oxygen species and hypoxic pulmonary vasoconstriction Exp Physiol, September 1, 2007; 92(5): 819 - 820. [Full Text] [PDF]