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Experimental Physiology 92.6 pp 988-991
DOI: 10.1113/expphysiol.2006.036343
© The Physiological Society 2007
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Regulation of tissue perfusion in mammals by hypoxia-inducible factor 1

 Gregg L. Semenza1

1 Vascular Biology Program and Institute for Cell Engineering, Departments of Pediatrics, Medicine, Oncology and Radiation Oncology; and McKusick-Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

Abstract

The regulation of tissue perfusion is a major mechanism by which oxygen homeostasis is maintained. Hypoxia-inducible factor 1 (HIF-1) is a transcriptional regulator that mediates adaptive responses to reduced partial pressure of O2 in all metazoan species. In mammals, HIF-1 promotes angiogenesis, arteriogenesis and vasculogenesis through the production of multiple angiogenic growth factors in ischaemic tissue and by cell-autonomous effects on endothelial cells and bone marrow-derived angiogenic cells. Administration of viral vectors encoding constitutively active forms of the HIF-1{alpha} subunit results in increased tissue perfusion in animal models of ischaemic cardiovascular disease.

(Received 17 May 2007; accepted after revision 14 August 2007; first published online 24 August 2007)
Corresponding author G. L. Semenza: Broadway Research Building, Suite 671, 733 North Broadway, Baltimore, MD 21205, USA. Email: gsemenza{at}jhmi.edu




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