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This Article Full Text Full Text (PDF) All Versions of this Article: 92/6/992    most recent expphysiol.2006.036350v1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lee, N. H. Search for Related Content PubMed PubMed Citation Articles by Lee, N. H. Related Collections Genomic Physiology Symposia Papers

¹ Department of Pharmacology and Physiology, The George Washington University Medical Center, Washington, DC, USA ² Department of Functional Genomics, The Institute for Genomic Research, Rockville, MD, USA

Abstract

As is the case for many human disorders, cardiovascular disease is a complex ailment exhibiting a multifactorial mode of transmission. Rat models have been developed to aid in the analysis of this complex genetic and phenotypic disorder. The purpose of this brief review is to describe current gene expression profiling strategies that have been implemented to search for candidate causative genes of disease phenotypes in animal models. Strategies include integrating gene expression information with linkage analysis, expression profiling chromosome-substituted and/or congenic rat strains, correlating gene expression with physiological data across a panel of rodent strains, and linking expression quantitative trait loci to physiological quantitative trait loci. A primary goal of these strategies is to narrow and prioritize the search for causal genes of physiological interest. Also discussed are ways to harness two recent publicly available resources that have been created to investigate the role of genes and environment on cardiovascular physiology and pathophysiology.

(Received 23 May 2007; accepted after revision 25 June 2007; first published online 25 June 2007)
Corresponding author N. H. Lee: Department of Pharmacology and Physiology, The George Washington University Medical Center, 2300 Eye Street NW, Washington, DC 20037, USA. Email: phmnhl{at}gwumc.edu

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