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This Article Full Text Full Text (PDF) All Versions of this Article: 93/4/479    most recent expphysiol.2007.040972v1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Judge, A. R. Articles by Dodd, S. L. Search for Related Content PubMed PubMed Citation Articles by Judge, A. R. Articles by Dodd, S. L.

¹ Muscle Physiology Laboratory, Department of Applied Physiology and Kinesiology, University of Florida, Box 118206, Gainesville, FL 32611, USA

We have previously shown oxidative stress and oedema, caused by both xanthine oxidase-derived oxidants and infiltrating neutrophils, within skeletal muscle after contractile-induced claudication. The purpose of this study was to determine whether supplementation with antioxidant vitamins attenuates the oxidative stress, neutrophil infiltration and oedema associated with an acute bout of contractile-induced claudication. Rats received vehicle, vitamin C, vitamin E or vitamin C + E for 5 days prior to contractile-induced claudication. Force production was significantly reduced in the claudicant limbs of all groups compared with the control (sham) limb of control animals. Contractile-induced claudication caused a significant increase in protein oxidation, lipid peroxidation, neutrophil infiltration and oedema compared with sham muscles. Supplementation with vitamin C, E or C + E prevented the increases in each of these, and there were no differences between groups. These findings suggest that, in an animal model of exercise-induced claudication, neutrophil chemotaxis is caused by oxidizing species and that antioxidant supplementation can prevent oxidative damage, neutrophil infiltration and oedema following an acute bout of contractile-induced claudication.

(Received 3 October 2007; accepted after revision 10 January 2008; first published online 25 January 2008)
Corresponding author A. R. Judge: PO Box 118205, University of Florida, Gainesville, FL 32611, USA. Email: ajudge{at}hhp.ufl.edu