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This Article Full Text Full Text (PDF) All Versions of this Article: 93/5/538    most recent expphysiol.2007.040014v1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Google Scholar Articles by Gurley, S. B. Articles by Coffman, T. M. PubMed PubMed Citation Articles by Gurley, S. B. Articles by Coffman, T. M. Related Collections Review Articles Genomic Physiology

¹ Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, NC, USA

As a major regulator of blood pressure homeostasis, the renin–angiotensin system (RAS) has been the subject of extensive scientific investigation. While the RAS was first discovered more than 100 years ago, several novel components of the system have been identified only in the last decade. One of these newer members of the RAS family is angiotensin-converting enzyme 2 (ACE2). Among the approaches used to establish a physiological role for ACE2 has been the generation of ACE2-null mouse lines using homologous recombination in embryonic stem cells. In the literature, there have been at least three lines of ACE2 knockout mice generated by gene targeting by different investigative groups. Interestingly, there are significant differences in some of the reported phenotypes of these distinct lines, especially with regard to their cardiovascular physiology. In this paper, we will review the results of published experiments using these ACE2-null mouse lines, highlighting similarities and differences in these studies and summarizing their contributions to our understanding of the physiological functions of this novel member of the RAS.

(Received 10 February 2008; accepted after revision 27 February 2008; first published online 30 March 2008)
Corresponding author T. M. Coffman: Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Nephrology Research, DUMC 103015, Durham, NC 27710, USA.  Email: tcoffman{at}duke.edu

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				M. K. Raizada and J. F. R. Paton Recent advances in the renin-angiotensin system: angiotensin-converting enzyme 2 and (pro)renin receptor Exp Physiol, May 1, 2008; 93(5): 517 - 518. [Full Text] [PDF]