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Experimental Physiology 89.4 pp 341
© The Physiological Society 2004
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Author's Response

Author's response to C. John Dickinson's commentary

Terry N. Thrasher

Department of Surgery, School of Medicine, University of Maryland, Baltimore, MD, USA

(Received 16 February 2003; accepted after revision 4 May 2004; first published online 6 May 2004)
Concerning your comment that ‘... Vatner et al. (1970) were not able to reduce arterial pressure for more than a few minutes in conscious dogs by electrical stimulation of the carotid sinus nerves'. At the time I wrote the article, I missed an important observation from Lohmeier's laboratory (Lohmeier et al, 2004). They implanted electrodes around the carotid sinus nerves and stimulated the nerves continuously for 7 days in conscious dogs. They reported a sustained fall in MAP that averaged about 20 mmHg below control together with a decrease in both heart rate and plasma norepinephrine concentration. Regardless of arguments about the time course or degree of baroreceptor resetting, Lohmeier's results clearly show that the baroreflex pathway does not adapt over a 7 day period.

References

Vatner SF, Franklin D, Van Citters RL & Braunwald E (1970). Effects of carotid sinus nerve stimulation on blood-flow distribution in conscious dogs at rest and during exercise. Circulat Res 79, 543–550.

Lohmeier TE, Irwin ED, Rossing MA, Serdar DJ & Kieval RS (2004). Prolonged activation of the baroreflex produces sustained hypotension. Hypertension 43, 306–311.[Abstract/Free Full Text]





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