Experimental Physiology Celebrating 100 years
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Experimental Physiology 90.1 pp 25
DOI: 10.1113/expphysiol.2005.900003
© The Physiological Society 2005
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Symposium Report

Viral gene transfer in neuroscience: new tricks of the trade

Viral gene transfer in neuroscience: new tricks of the trade

Sergey Kasparov and Julian F. R. Paton

This issue contains a series of papers generated by the speakers at a recent focused meeting entitled Viral gene transfer in neuroscience: new tricks of the trade which was held at the University of Bristol on the 4–5th of September 2004.

During the last decade, viral vectors have become reliable tools for gene manipulation in the brain, which can be efficiently used to elucidate the roles of individual genes and their families under normal and pathological conditions. Several types of vectors, including lentiviral vectors, adenoviral vectors, adeno-associated viral vectors, baculovirus-based vectors and alphavirus-derived vectors are currently being used. All these viruses offer distinct advantages for neuroscience. Their molecular features, technical aspects of their production and application are described in the papers that follow in this volume. The reader will also have a feel for the spectrum of applications of viral gene transfer in physiological experimentation both in vivo and in vitro and the forthcoming developments of this exciting technology.

The papers reflect the content of most of the presentations with the exception of two by Professors Beverley Davidson (University of Iowa, Iowa, USA) and Mohan Raizada (University of Florida, Gainesville, USA).

We are most grateful to the Physiological Society, Pfizer UK and the Department of Physiology, University of Bristol, for their financial support.




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