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Experimental Physiology 89.6 pp 657-664
DOI: 10.1113/expphysiol.2004.027839
© The Physiological Society 2004
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Paroxetine administration to influence human exercise capacity, perceived effort or hormone responses during prolonged exercise in a warm environment

A. T Strachan1, J. B Leiper2 and R. J Maughan3

1 Department of Clinical Biochemistry, Grampian University Hospital NHS Trust, Foresterhill, Aberdeen, AB25 2ZD, UK 2 School of Medical Sciences, University Medical School, Foresterhill, Aberdeen, AB25 2ZD, UK 3 School of Sport & Exercise Sciences, Loughborough University, Loughborough, Leicestershire, LE11 3TU, UK

The purpose of the experiment was to examine whether selective serotonin (5-HT) re-uptake transporter blockade by paroxetine has any effect on perceived effort (RPE) during exercise or the time to reach volitional fatigue and on the prolactin and cortisol responses during prolonged exercise performed in a warm environment. Eight healthy males performed two cycle rides to exhaustion in a warm (32°C) environment at 60% of maximum oxygen uptake. Paroxetine (20 mg) or placebo was administered 5 h before exercise trials in a randomised double blind fashion. Time to exhaustion was not significantly influenced by administration of paroxetine: median (range) time to exhaustion was 93.3 (76.2–175.0) min on the placebo trial and 92.5 (66.0–151.0) min on the paroxetine trial. Rectal temperature was higher at rest and throughout exercise on the paroxetine trial. The serum concentrations of prolactin and cortisol were determined throughout exercise as peripheral markers of central 5-HT activity. RPE increased over time but was not influenced by paroxetine administration. Prolactin and cortisol levels increased over time but paroxetine administration did not influence the hormone responses during exercise. In conclusion, acute administration of paroxetine failed to alter RPE, exercise capacity or the response of the determined peripheral hormone markers of central 5-HT activity during prolonged exercise in a warm environment.

(Received 20 April 2004; accepted after revision 17 July 2004; first published online 24 August 2004)
Corresponding author A. T. Strachan: Department of Clinical Biochemistry, Grampian University Hospital NHS Trust, Foresterhill, Aberdeen, AB25 2ZD, UK. Email: a.t.strachan{at}arh.grampian.scot.nhs.uk






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