Experimental Physiology Celebrating 100 years
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Experimental Physiology 93.1 pp 83-94
DOI: 10.1113/expphysiol.2007.040733
© The Physiological Society 2008
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
93/1/83    most recent
expphysiol.2007.040733v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Thireau, J.
Right arrow Articles by Babuty, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Thireau, J.
Right arrow Articles by Babuty, D.

Heart rate variability in mice: a theoretical and practical guide

 J. Thireau1, B. L. Zhang1, D. Poisson1 and D. Babuty1

1 Centre National de Recherche Scientifique, Unité Mixte de Recherche 6542, Laboratoire de Physiologie des Cellules Cardiaques et Vasculaires, Université François-Rabelais, Tours, France

The mouse is the animal model principally used to study biological processes in mammals. The mutation, overexpression or knockout of one or several genes can provide insight into human disease. In cardiovascular research, evaluation of autonomic nervous function is an essential tool for a better understanding of the pathophysiological conditions in which cardiomyopathy arises and develops. Analysis of heart rate variability is the least invasive method to evaluate the sympathovagal balance on the sino-atrial level. The need to perform this technique on freely moving mice emerged in the 1990s, but despite previous studies it has been difficult to set up and standardize a common protocol. The multitudes of techniques used, plus subtle differences in methodology, impede the comparison and clear interpretation of results. This article aims to make a survey of heart rate variability analysis and to establish a standardized protocol for the assessment of the autonomic neural regulation of heart rate in mice.

(Received 14 September 2007; accepted after revision 20 September 2007; first published online 2 October 2007)
Corresponding author D. Babuty: CNRS, UMR 6542, Physiologie des Cellules Cardiaques et Vasculaires, Université François-Rabelais, Faculté des Sciences, 31 Avenue Monge, Parc de Grandmont, 37200 Tours, France. Email: d.babuty{at}chu-tours.fr






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2008 by the The Physiological Society.