Received January 8, 2004
Revised January 20, 2004
Accepted after revision January 30, 2004
Neuroendocrinology/endocrinology
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The expanding family of -RFamide peptides and
their effects on feeding behaviour
Graham J Dockray 1*
1 University of Liverpool
* To whom correspondence should be addressed. E-mail: g.j.dockray{at}liverpool.ac.uk.
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Abstract |
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Neuropeptides terminating in -Arg-Phe-NH2 (-RFamide) were first discovered in molluscan nervous systems, but were soon recognised to occur widely throughout the invertebrates. Progress in characterising vertebrate members of the family has been slower. In mammals, however, it is now clear that there are at least five genes encoding members of the family, and at least five G-protein coupled receptors at which they act. The tissue distribution of the peptides and their receptors is wide and there are likely to be many different functions. One of the emerging themes from recent research is that these peptides are involved in control of feeding behaviour both in invertebrates and in vertebrates. This would seem to be a remarkable example of conservation of chemical structure and biological function throughout nervous system evolution.
Key Words:
Hypothalamus, Neuroendocrinology, Nucleus tractus solitarii
