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First published online on June 7, 2004.
Experimental Physiology (2004)
DOI: 10.1113/expphysiol.2004.027789
© The Physiological Society 2004
A more recent version of this article appeared on September 1, 2004
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Received April 7, 2004
Revised April 27, 2004
Accepted after revision May 24, 2004

Neuroendocrinology/endocrinology

Gut hormones in the control of appetite

Kevin Graeme Murphy 1 Stephen R Bloom 1*

1 Imperial College

* To whom correspondence should be addressed. E-mail: s.bloom{at}imperial.ac.uk.


  Abstract
Obesity is one of the greatest threats to the health of the developed world. In order to design effective drugs to treat the alarming increase in obesity, it is essential to understand the physiology of normal appetite control and the pathophysiology of obesity. The hypothalamus interprets and integrates neural and humoral inputs to provide a coordinated feeding and energy expenditure response. Recent evidence suggests that certain gut hormones- ghrelin, polypeptide YY, pancreatic polypeptide, glucagon-like-peptide 1 and oxyntomodulin- have a physiological role in governing satiety via the hypothalamus. Gut hormone appetite-regulatory systems represent a potential target for the design of anti-obesity drugs.

Key Words: Endocrinology, Gut, Obesity




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