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First published online on February 22, 2005.
Experimental Physiology (2005)
DOI: 10.1113/expphysiol.2004.029322
© The Physiological Society 2005
A more recent version of this article appeared on May 1, 2005
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Received January 12, 2005
Revised February 3, 2005
Accepted after revision February 17, 2005

Genomic physiology

GENETIC ANALYSIS OF COMPLEX CARDIOVASCULAR TRAITS IN THE SPONTANEOUSLY HYPERTENSIVE RAT

Michal Pravenec 1* Vladimír Kren 2

1 Czech Academy of Sciences, Prague
2 Charles University, Prague

* To whom correspondence should be addressed. E-mail: pravenec{at}biomed.cas.cz.


  Abstract
Identification of genetic determinants of common diseases is a major challenge of the current biomedical research. Combining linkage analyses of essentially monogenic cis-regulated expression phenotypes with oligogenic intermediate physiological phenotypes represents a promising approach for identification of quantitative trait loci at the molecular level. In the current review, a genetic analysis of cardiovascular phenotypes studied at several levels of complexity in rat recombinant inbred strains is described.

Key Words: Gene expression, Hypertension, Rat






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