Received January 6, 2005
Revised January 28, 2005
Accepted after revision February 21, 2005
Effect of anti-inflammatory and antioxidant drugs
on the long-term repair of severely injured skeletal muscle
Alban Vignaud 1,
José Cebrian 1,
Isabelle Martelly 1,
Jean-Pierre Caruelle 1,
Arnaud Ferry 1*
1 Université Paris 12, CNRS
* To whom correspondence should be addressed. E-mail: ferry{at}univ-paris12.fr.
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Abstract |
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Non-steroidal anti-inflammatory drugs are frequently prescribed after skeletal muscle injury. It is not known whether this type of medication can interfere with muscle repair although inflammatory response is thought to play an important role in this process. Tibialis anterior muscles of mice were injured by myotoxic agent (snake venom) or crushed. Then, animals were daily treated during 10-14 days with different types of non-steroidal anti-inflammatory and anti-oxidant drugs. The long-term repair was studied 10-42 days after injury by analysing the muscle recovery of in situ force production, size of regenerating muscle cells and expression of myosin heavy chain. Our results show that diclofenac, diferuloylmethane (curcumin), dimethylthiourea, or pyrrolidine dithiocarbamate treatment did not significantly affect muscle recovery after myotoxic injury (p > 0.05). Similarly, diferuloylmethane, dimethylsulfoxide, or indomethacin administration did not markedly change muscle repair after crush injury. However, we noted that high doses (> 2 mg/kg) of diferuloylmethane or indomethacin increased lethality and reduced muscle repair after crush injury. In conclusion, non-steroidal anti-inflammatory and antioxidant drugs did not exhibit long-term detrimental effect on muscle recovery after injury, except at lethal doses.
Key Words:
Inflammation, Pathology, Skeletal muscle
