Received May 8, 2005
Revised May 24, 2005
Accepted after revision August 12, 2005
GI and epithelial physiology
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Extremely low electrical current generated by porcine small intestine smooth muscle alters bacterial autolysin production
Dauta Kruszewska 1,
Pawel Podgurniak 2,
Åsa Ljungh 1,
Aleksandra Sebastian 1,
Lenart Larsson 1,
Jolanta Zajdel-Dabrowska 3,
Marta Dabek 4,
Stefan G Pierzynowski 1*
1 Lund University
2 Warsaw Agricultural University
3 Medical University Warsaw
4 Fisheries Institute, Gdynia
* To whom correspondence should be addressed. E-mail: stefan.pierzynowski{at}telia.com.
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Abstract |
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The effect of extremely low electrical currents, identical to those generated by the gut smooth muscle on bacterial autolysin production in vitro, was tested in the present study. When stimulated with these electrical currents, the bacteria Pediococcus pentosaceus 16:1 produced groups of peptidoglycan hydrolases that differed from those produced by the unstimulated bacteria. The autolysins synthesized by the P. pentosaceus 16:1 under extremely low electrical currents were effective against peptidoglycans from the cell walls of various lactic acid bacteria strains, whereas the autolysins from the control acted exclusively against P. pentosaceus 16:1 cell walls. Thus, it can be predicted that in vivo the electrical currents generated by the intestinal smooth muscles, and recorded as the myoelectrical migrating complexes, could regulate lactic acid bacteria strain growth in the gut.
Key Words:
Electrical activity, Intestine, Smooth muscle
