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Physiology in Press

First published online on September 12, 2005.
Experimental Physiology (2005)
DOI: 10.1113/expphysiol.2005.030924
© The Physiological Society 2005
A more recent version of this article appeared on November 1, 2005
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Received August 8, 2005
Revised August 30, 2005
Accepted after revision September 7, 2005

Renal physiology

Hypoxia-inducible Factor as a physiological regulator

Patrick H Maxwell 1*

1 Imperial College London

* To whom correspondence should be addressed. E-mail: p.maxwell{at}imperial.ac.uk.


  Abstract
Hypoxia-Inducible Factor (HIF) is a transcription complex which responds to changes in oxygen, providing cells with a master regulator coordinating changes in gene transcription. HIF operates in all mammalian cell types, and is ancient in evolutionary terms - being conserved in C. elegans and D. melanogaster. This review summarises recent insights into the molecular events which link reduced oxygenation to HIF activation, and emerging insights into the extensive role of HIF in a broad range of physiological processes.

Key Words: Oxygen, Renal






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