Received October 13, 2005
Revised November 16, 2005
Accepted after revision January 10, 2006
Heart/Cardiac Muscle [240]
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Electrophysiological Effects of Mechano-Sensitive Ion Channels on Ventricular Electrophysiology: Experimental and Theoretical Models
Peter Kohl 1*,
Christian Bollensdorff 1,
Alan Garny 1
1 University of Oxford
* To whom correspondence should be addressed. E-mail: peter.kohl{at}physiol.ox.ac.uk.
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Abstract |
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The heart is an electrically driven mechanical pump, somewhat like an electric motor. Interestingly, like an electric motor in 'dynamo mode', the heart can also convert mechanical stimuli into electrical signals. This feedback from cardiac mechanics to electrical activity involves mechano-sensitive ion channels, whose properties and patho physiological relevance are reviewed in the context of experimental and theoretical modelling of ventricular beat-by-beat electro-mechanical function.
Key Words:
ATP, ECG, Stretch-activated channel
