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First published online on November 10, 2005.
Experimental Physiology (2005)
DOI: 10.1113/expphysiol.2005.032060
© The Physiological Society 2005
A more recent version of this article appeared on January 1, 2006
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Received August 30, 2005
Revised October 5, 2005
Accepted after revision November 7, 2005

Vascular physiology

EFFECT OF ESTROGEN AND ANGIOTENSIN-CONVERTING ENZYME INHIBITOR ON THE MICROVASCULATURE FROM OVARIECTOMIZED SPONTANOUSLY HYPERTENSIVE RATS

Jose Giménez 1, Maria Paz Garcia 2, Barbara Bonacasa 2, Luis F Carbonell 2, Tomas Quesada 2, Isabel Hernandez 2*

1 University of Murcia
2 Universidad de Murcia

* To whom correspondence should be addressed. E-mail: isabelhg{at}um.es.


  Abstract
OBJECTIVE: to investigate the role of estrogen in the function and structure of the microcirculation in female SHR and to evaluate the effect of 17{beta}-estradiol on the cardiovascular response to pharmacological agents which block the formation of angiotensin II. DESIGN: 10 weeks old female spontaneously hypertensive rats were randomized to intact, ovariectomized or ovariectomized rats treated with 17{beta}-estradiol (1.5mg/ 60 days) and/or captopril (5 mg/kg/day; 60 days). Systolic blood pressure was determined from time of ovariectomy until 18 weeks and at this age, endothelial function and microvascular density in skeletal muscle were evaluated. RESULTS: 17{beta}-estradiol or captopril prevented development of hypertension in ovariectomized rats. Furthermore, coadministration of captopril and 17{beta}-estradiol had a greater antihypertensive effect than each treatment alone. Vasodilatation in response to acetylcholine was impaired in ovariectomized spontaneously hypertensive rats, and this effect was improved by both, 17{beta}-estradiol or captopril treatments. In addition, 17{beta}-estradiol replacement in ovariectomized rats enhanced the effect of captopril on vasodilatation induced by acetylcholine. Ovariectomized rats showed a lower microvascular density than intact rats. 17{beta}-estradiol replacement or captopril treatment prevented the effect of ovariectomy and indeed, the effect on microvascular density induced by captopril or estradiol alone was significantly increased by coadministration of both. CONCLUSIONS: 17{beta}-estradiol or captopril attenuated the development of hypertension and improved the impairment of microvascular density in ovariectomized spontaneously hypertensive rats. Moreover, simultaneously administration of both, estradiol and captopril exerted a further additive effect on blood pressure and microvasculature.

Key Words: Endothelium, Hypertension, Vascular blood flow






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