Received April 17, 2006
Revised May 10, 2006
Accepted after revision May 10, 2006

¹ The Johns Hopkins University School of Medicine

^* To whom correspondence should be addressed. E-mail: gsemenza{at}jhmi.edu.

	Abstract

Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor composed of HIF-1a and HIF-1b subunits that functions as a master regulator of oxygen homeostasis. O2-dependent hydroxylation of HIF-1a provides a mechanism that allows changes in oxygenation to be transduced to the nucleus, leading to changes in gene expression. HIF-1 plays critical roles in development, physiology, and disease pathogenesis. Analyses of mice that are heterozygous for a null allele at the locus encoding the HIF-1a subunit have demonstrated that partial deficiency of HIF-1 is sufficient to impair multiple physiological responses to continuous and intermittent hypoxia.

Key Words: Carotid body, Hypoxia, Pulmonary circulation

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