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First published online on March 9, 2007.
Experimental Physiology (2007)
DOI: 10.1113/expphysiol.2006.035642
© The Physiological Society 2007
A more recent version of this article appeared on May 1, 2007
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Received December 15, 2006
Revised February 8, 2007
Accepted after revision March 7, 2007

Neuroendocrinology/Endocrinology [270]

Hydromineral Neuroendocrinology Symposium: CNS control of osmoregulation;molecular perspective. TRPV ion channels' role in sensory transduction of osmotic stimuli in mammals

Wolfgang Liedtke 1*

1 Duke University

* To whom correspondence should be addressed. E-mail: wolfgang{at}neuro.duke.edu.


  Abstract
In signal transduction of metazoan cells, ion channels of the family of transient receptor potential (TRP) have been identified to respond to diverse external and internal stimuli, amongst them osmotic stimuli. This report will highlight findings pertaining to the TRPV subfamily, focusing on mammalian members. Of the six mammalian TRPV channels, TRPV1, 2 and 4 were demonstrated to function in transduction of osmotic stimuli. TRPV channels have been found to function in cellular as well as systemic osmotic homeostasis. In a striking example of evolutionary conservation of function, mammalian TRPV4 has been found to rescue osmo-sensory deficits of the TRPV mutant strain osm-9 in C. elegans, despite not more than 26% orthology of the respective proteins.

Key Words: Ion channel, Osmoregulation




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