Experimental Physiology Celebrating 100 years
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Physiology in Press

First published online on November 23, 2006.
Experimental Physiology (2006)
DOI: 10.1113/expphysiol.2006.036434
© The Physiological Society 2006
A more recent version of this article appeared on January 1, 2007
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
92/1/39    most recent
expphysiol.2006.036434v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Prabhakar, N. R
Right arrow Articles by Kumar, G. K
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Prabhakar, N. R
Right arrow Articles by Kumar, G. K

Received November 3, 2006
Revised November 6, 2006
Accepted after revision November 6, 2006

Cardiovascular Control [210]

SYSTEMIC, CELLULAR AND MOLECULAR ANALYSIS OF CHEMOREFLEX- MEDIATED SYMPATHO-EXCITATION BY CHRONIC INTERMITTENT HYPOXIA

Nanduri R Prabhakar 1*, Thomas E Dick 1, Jayasri Nanduri 1, Ganesh K Kumar 1

1 CWRU

* To whom correspondence should be addressed. E-mail: nrp{at}po.cwru.edu.


  Abstract
Abstract Patients with recurrent apneas exhibit autonomic abnormalities manifested as persistent increase in sympathetic nerve activity (SNA). Several studies suggest that chronic intermittent hypoxia (CIH) resulting from recurrent apneas is a major stimulus for evoking autonomic morbidity. Although it has been proposed that CIH by way of activating chemoreceptor reflex leads to sympathetic excitation the underlying mechanisms are incompletely understood. Studies on experimental models provided new insights into the mechanisms associated with CIH-evoked sympatho- excitation. The purpose of this article is to highlight recent information on systemic, cellular and molecular analysis of the effects of CIH on chemoreceptor mediated sympatho-excitation. CIH exerts two major effects on the chemoreceptor-reflex pathway that includes: a) augmentation of the carotid body and sympathetic effector responses to acute hypoxia and b) induction of long-lasting activation of both the sensor and the effector that persists several hours after termination of CIH. Available evidence indicates that CIH may facilitate processing of chemoreceptor afferent information at the central nervous system. Recent studies suggest that reactive oxygen species (ROS)- mediated signaling is a major cellular mechanism, and transcriptional activation by hypoxia-inducible factor-1 is one of the critical molecular mechanism underlying chemoreceptor mediated sympatho-excitation by CIH.

Key Words: Cardiovascular, Carotid body, Hypoxia




This article has been cited by other articles:


Home page
 Exp. Biol. Med.Home page
T. V. Serebrovskaya, E. B. Manukhina, M. L. Smith, H. F. Downey, and R. T. Mallet
Intermittent Hypoxia: Cause of or Therapy for Systemic Hypertension?
Experimental Biology and Medicine, June 1, 2008; 233(6): 627 - 650.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. Pawar, Y.-J. Peng, F. J. Jacono, and N. R. Prabhakar
Comparative analysis of neonatal and adult rat carotid body responses to chronic intermittent hypoxia
J Appl Physiol, May 1, 2008; 104(5): 1287 - 1294.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
M. L. Smith
Sleep Apnoea and Hypertension: Physiological Bases for a Causal Relation Themed Issue
Exp Physiol, January 1, 2007; 92(1): 19 - 20.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Copyright © 2006 by the The Physiological Society.