Experimental Physiology Celebrating 100 years
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Physiology in Press

First published online on March 28, 2007.
Experimental Physiology (2007)
DOI: 10.1113/expphysiol.2006.036673
© The Physiological Society 2007
A more recent version of this article appeared on July 1, 2007
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
92/4/749    most recent
expphysiol.2006.036673v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lin, S.
Right arrow Articles by Yu, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lin, S.
Right arrow Articles by Yu, J.

Received November 21, 2006
Revised January 3, 2007
Accepted after revision March 13, 2007

Respiratory [290]

BEHAVIORS OF PULMONARY SENSORY RECEPTORS DURING DEVELOPMENT OF ACUTE LUNG INJURY IN THE RABBIT

Shuxin Lin 1, Jerome Walker 2, Ling Xu 3, David Gozal 1, Jerry Yu 1*

1 University of Louisville
2 Bellarmine University
3 James Madison University

* To whom correspondence should be addressed. E-mail: j0yu0001{at}louisville.edu.


  Abstract
We tested the hypothesis that oleic acid-induced acute lung injury activates pulmonary nociceptors, that is, C-fiber receptors (CFRs) and high-threshold Ad fiber receptors (HTARs). Single-unit activity was recorded in the cervical vagus nerve and assessed before and after injecting oleic acid (75µl/kg) into anesthetized, open-chest, and mechanically ventilated rabbits. Unit activities increased within seconds and peaked within a few minutes (from 0.3±0.1 to 1.4±0.9 imp/s for CFRs, and from 0.5±0.1 to 1.7±0.3 imp/s for HTARs, both n=8 and P<0.05). These activities were sustained while pulmonary edema developed and dynamic lung compliance decreased over the 90-minute observation period. Activities in slowly adapting receptors and rapidly adapting receptors were also increased; however, their responsiveness to airway pressure stimulation decreased progressively. We conclude that pulmonary nociceptors are stimulated during acute lung injury. The dual nociceptor system, consisting of both non-myelinated CFRs and myelinated HTARs, may play an important role in the pathophysiological process of acute lung injury-induced respiratory responses.

Key Words: Nociception, Pulmonary circulation, Respiratory control




This article has been cited by other articles:


Home page
 Exp PhysiolHome page
Y. Tan, T. Yang, S. Liu, H. Liu, Y. Xiang, F. Qu, H. Li, and X. Qin
Infection with respiratory syncytial virus alters peptidergic innervation in the lower airways of guinea-pigs
Exp Physiol, December 1, 2008; 93(12): 1284 - 1291.
[Abstract] [Full Text] [PDF]

Home page
 Integr. Comp. Biol.Home page
E. Spinelli Oliveira, J. T. Hancock, M. Hermes-Lima, D. A. Isola, M. Ochs, J. Yu, and D. Wilhem Filho
Implications of dealing with airborne substances and reactive oxygen species: what mammalian lungs, animals, and plants have to say?
Integr. Comp. Biol., October 1, 2007; 47(4): 578 - 591.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Copyright © 2007 by the The Physiological Society.