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Physiology in Press

First published online on February 28, 2007.
Experimental Physiology (2007)
DOI: 10.1113/expphysiol.2006.036897
© The Physiological Society 2007
A more recent version of this article appeared on May 1, 2007
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Received December 22, 2006
Revised February 8, 2007
Accepted after revision February 22, 2007

Neuroendocrinology/Endocrinology [270]

Angiotensin II receptor signaling

Derek Daniels 1*, Daniel K Yee 2, Steven J Fluharty 2

1 University at Buffalo, SUNY
2 University of Pennsylvania

* To whom correspondence should be addressed. E-mail: danielsd{at}buffalo.edu.


  Abstract
Angiotensin II plays a key role in the regulation of body fluid homeostasis. To address the body fluid deficits occurring during hypovolemia, an animal needs to ingest both water and electrolytes. Thus, it is not surprising that angiotensin II, which is synthesized in response to hypovolemia, acts centrally to increase both water and NaCl intake. Here, we review findings related to the properties of angiotensin II receptors that give rise to changes in behavior. Data are described to suggest that divergent signal transduction pathways are responsible for separable behavioral responses to angiotensin II and a hypothesis is proposed to explain how this divergence may map on to neural circuits in the brain.

Key Words: Angiotensin, Cell signalling, Receptor




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