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Cover illustration from Hippocampal neurones visualised using confocal microscopy and adenovirus-mediated expression of green fluorescent protein in cultured organotypic brain slices (image provided by Drs. S. Kasparov and A.G. Teschemacher). Such images and techniques are further illustrated in a series of papers in this issue (27-69) that were based on a symposium entitled Viral gene transfer: new tricks of the trade organised by Sergey Kasparov and Julian Paton at the University of Bristol, Bristol, UK.