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The cover illustration shows the following images, clockwise from top-left. (i) Rat brain injected with AdLacZ; rat rolled to one side for 30 min to transduce one hemisphere; taken from Ooboshu H, Welsh MJ, Rios CD, Davidson BL & Heistad DD (1995) Adenovirus-Mediated Gene Transfer In Vivo to Cerebral Blood Vessels and Perivascular Tissue, Circ Res 77, 7-13 with permission from Lippincott Wiliams and Wilkins (supplied by donald-heistad@uiowa.edu). (ii) Cos 1 cells transduced with AdMnSOD in vitro (supplied by donald-heistad@uiowa.edu). (iii) Heart transduced with the lentiviral vector; taken from Coleman JE, Huentelman MJ, Kasparov S, Metcalfe BL, Paton JF, Katovich MJ, Semple-Rowland SL & Raizada MK (2003) Efficient large-scale production and concentration of HIV-1 based lentoviral vectors for use in vivo, Physiol Genomics 12, 221-228 with permission from The American Physiological Society (supplied by Mohan Raizada: mraizada@phys.med.ufl.edu). (iv) Kidney transduced with the lentiviral vector (supplied by Mohan Raizada: mraizada@phys.med.ufl.edu).