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The cover illustration is a confocal image showing a mouse mesenteric artery stained with a nuclear dye (SYTO 62 1 μg ml^-1, red) and a flourescent alpha1-adrenoceptor ligand (QAPB 0.1 m, green). All smoothmuscle cells stain positive for QAPB and thus contain alpha1-adrenoceptors. A population of cells in the adventitia also expresses alpha1-adrenoceptors. The endothelial cells (identified by their nuclei) can be see running through the centre of the vessel and appear to be aligned with the folds in the internal elastic lamina of this un-pressurised vessel. The adventitia is densely populated with cells (red nuclei). Adventitial nerve fibres travelling parallel to the vessel are also visible. The unusual looking structure at the bottom of the image is a small arteriole which appears to express high levels of alpha1-adrenoceptors. Supplied by Craig Daly, Majid Shafaroudi and Ian McGrath.