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The cover illustration shows the central and peripheral effects of leptin on blood pressure. Despite the potential vasodilatory effects of leptin, sympathetically mediated pressor effects predominate in vivo. The metabolic and renal sympathetic actions of leptin are mediated by different neuronal pathways. α-MSH, α-melanocyte-stimulating hormone; BAT, brown adipose tissue; CRF, corticotrophin releasing hormone; SNA, sympathetic nerve activity; NPY, neuropeptide Y. Supplied by W. G. Haynes.