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The cover illustration shows regulation of the HIF complex by oxygen through hydroxylation of the α subunit. There are three hydroxylation sites: two propyl residues in the oxygen-dependent destruction domain and an asparaginyl residue in the C terminal transactivation domain. In the presence of molecular oxygen these are hydroxylated by PHD and FIH enzymes, respectively. The propyl hydroxylation allows capture by VHL, leading to ubiquitylation and destruction, and the asparaginyl hydroxylation blocks transactivator recruitment. Maxwell (p. 791–797).