Experimental Physiology
	

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INSTRUCTIONS TO AUTHORS

Scope

Policy

Subject areas
Editorial procedures
Overlapping material
Conflict of interest
Ethical standards
Copyright and reproduction
Declaration of Helsinki

Publication costs

Administrative Procedures

Submissions
Correspondence
Date of receipt
Proofs
Offprints

Preparation of Manuscripts

General information
Arrangement of papers
References
Figures and legends
Supplemental material
Abbreviations
Symbols, units and mathematical notation
Chemical and biological nomenclature

 


Last updated: 6 May 2008

Information for Wellcome Trust- and NIH-funded authors.

Experimental Physiology does not impose submission or page charges. Authors can make their papers immediately freely available online through Blackwell Publishing's Online Open

 

SCOPE

Experimental Physiology publishes the following types of papers:

  1. Research Papers which report the results of original research;
  2. Hot Topic Reviews [PDF] which provide an accessible synthesis of current information in topical areas of physiology. These are normally limited to 3000 words and usually solicited by the Editorial Board;
  3. Review Articles [PDF] which discuss, critically and concisely, current developments of interest to physiologists. These are normally limited to about 20 printed pages and are solicited by the Editorial Board;
  4. Symposium Reports [PDF] which report concisely presentations given as part of symposia at scientific meetings.
  5. Exchange of Views [PDF] which present two opposing opinions on a topical subject published with commentary and responses from each participating author.
  6. Viewpoints [PDF] which discuss a selected article within the issue.
  7. Lectures [PDF] in which the author reports their invited lecture.
  8. Themed Issue papers which can take the form of any of the above paper types focusing on the specified 'Theme'.

POLICY

Subject areas

Experimental Physiology publishes articles in most areas of physiology (see table below). Papers should embrace the journal's new orientation of translation and integration. Specifically, we are keen to receive manuscripts that deal with both physiological and pathophysiological questions that investigate gene/protein function using molecular, cellular and whole animal approaches. In addition pertinent methodological papers are encouraged as are manuscripts that use computational models to further our understanding of physiological processes. The journal also publishes invited reviews dealing with rapidly developing areas of physiology or which update understanding of classical fields of physiology.

Editorial procedures

Members of the Editorial Board are responsible for editing a paper or assigning it to an appropriate Expert Referee. It is the policy of Experimental Physiology that each paper is independently reviewed by two Expert Referees, overseen by the relevant Editor. It is the aim of the Editorial Board that authors should receive an Editorial Report within 6 weeks of receipt of the complete manuscript in the Publications Office.

When submitting a manuscript authors should specify one of the subject areas listed below:

Subject area Relevant Editor(s)
1 Autonomic neuroscience J. Deuchars/J. F. R. Paton/J. Stern
2 Cardiovascular control M. Brown/G. Billman/S. Malpas/K. Patel
3 Computational physiology I. Efimov/N. Smith
4 Genomic physiology M. Raizada
5 GI and epithelial physiology P. Fong/N. Simmons
6 Heart/cardiac muscle P. Madeddu/D. J. Paterson/M. Shattock/G. L. Smith/W.Giles
7 Human/environmental and exercise physiology P. Raven/M. White
8 Muscle physiology K.Baldwin/S. Harridge/M. Hogan
9 Neuroendocrinology/endocrinology C. Coen/D.Murphy
10 Placental–perinatal S. Langley-Evans
11 Renal physiology N.Simmons
12 Respiratory physiology P. McLoughlin/N. Prabhakar
13 Vascular physiology K. Channon/S. Egginton

Authors are also encouraged to supply the names of up to three referees.

Overlapping material

Only in exceptional circumstances may results submitted for publication in Experimental Physiology repeat findings already published or intended to be published by the authors elsewhere; inclusion on a web site of material other than an abstract is considered as prior publication. Authors should instead refer to their previous findings in the same way as they would if the work had come from a different group. This policy applies to results in the widest sense and not simply to figures or parts of figures. The Editorial Board emphasizes that a manuscript which is merely an expanded version of work published elsewhere is not acceptable. An exception to this policy applies in the case of an abstract that does not exceed about 400 words.

A submission must be accompanied by copies of any material, published by the authors in the last year, that overlaps the content of the manuscript. This should include preliminary notes, communications, abstracts, chapters or reviews. Please also include any ‘in press’ or submitted articles. These should be submitted as ‘Supplemental files’ in PDF format, and reference made to them in the authors’ covering letter.

Conflict of interest

Using the covering letter on the electronic manuscript submission form, authors are required to disclose any potential conflict of interest such as consultancies, financial involvement, patent ownership, etc. Where such information is not already disclosed in the manuscript, it will be held in confidence during the review process. Should the article be accepted for publication the relevant information will be given in the Acknowledgements.

Ethical standards

Authors should note that the processing of papers may be delayed if there is any doubt about their conformity with the ethical standards required by Experimental Physiology.

1. Research misconduct

The Editorial Board is alert to any form of research or publication misconduct including submission of fraudulent data, plagiarism, dual publication and false or incomplete attribution of authorship. It endorses the general principles set out in Guidelines on Good Publication Practice produced by the Committee on Publication Ethics (COPE). The Guidelines are available from the web on: www.publicationethics.org.uk

Authors should be aware that Experimental Physiology will take action along the lines indicated in the COPE Guidelines where misconduct is suspected.

2. Animal experiments

The Editorial Board will not allow the publication of papers describing experimental procedures on living animals which may reasonably be presumed to have inflicted unnecessary pain or discomfort upon them.

To be acceptable for publication, experiments on living vertebrates or Octopus vulgaris should conform with the principles of UK legislation. Whenever appropriate, a statement should be included indicating that experiments were performed in accordance with national/local ethical guidelines. Authors must give a full description of their anaesthetic and surgical procedures, and of peri-operative care, at every stage (including preparatory stages). Where work involves decerebrate animals the level of section must be specified; destruction of tissue rostral to the section must be included as an essential part of the technique. For anaesthesia the following details are required:

(1) generic name for the anaesthetic;

(2) dose and route used;

(3) dose, route and frequency of supplemental doses, plus criteria for giving additional doses when neuromuscular blocking agents are used.

Note that chilling is not an acceptable method for rendering cold-blooded vertebrates insentient; an anaesthetic agent must be used. Authors must provide evidence that they took adequate steps to ensure that animals did not suffer unnecessarily at any stage of an experiment, whether acute or chronic. Where relevant, the fact that animals were killed at the end of an experiment should be stated.

Authors working on isolated tissues, including primary cell cultures, must state whether the donor animal was anaesthetized or killed, and give details of the relevant procedures. Where tissues are obtained from an abattoir or similar establishment the method of killing need not be specified unless scientifically important.

Use of neuromuscular blocking agents and of nitrous oxide

In experiments involving the use of neuromuscular blocking agents authors must describe the precautions taken to ensure the adequacy of anaesthesia. They must provide sufficient detail to enable the reader to determine that no unnecessary suffering occurred. The Physiological Society has issued the following advice: ‘When neuromuscular blocking agents are used with anaesthetic agents during physiological experiments, safeguards are required to ensure that the animal does not experience unnecessary pain or distress. It is the responsibility of the person conducting the experiment to ensure that anaesthesia is adequate. Neuromuscular blocking agents should never be used without anaesthesia.

(1) For any experiment using neuromuscular blocking agents it should first be established that the proposed anaesthetic regime is adequate, in the absence of these agents, to provide analgesia for any surgical procedure or noxious stimulus which is proposed. When light levels of anaesthesia are considered appropriate for experimental purposes, it should have been established that deeper levels of anaesthesia would interfere with the purpose of the experiment. All preparatory major surgery should be performed under full surgical anaesthesia. Subsequent procedures under light anaesthesia in the presence of neuromuscular blocking agents should be conducted in such a way that any residual pain from the initial surgery is blocked by local anaesthetics or analgesia and no further noxious stimuli are delivered. It should be noted that some methods of head holding using ear bars and zygomatic bars are a potential source of pain: other, atraumatic, methods of head restraint should be used in lightly anaesthetized animals.

(2) During the course of each experiment in the period when neuromuscular blocking agents are used there must be a protocol for continuous or regular assessment of adequacy of anaesthesia. The appropriate methods of assessment will depend on the particular anaesthetic and the particular experiment. For example:

(a) the monitoring of changes in heart rate and blood pressure provides one of the most valuable indices of the level of anaesthesia. Neuromuscular blocking agents, in doses which do not reduce blood pressure, do not abolish autonomic cardiovascular reflexes. A preparation in which precipitate cardiovascular responses occur to minor noxious stimuli must be considered too lightly anaesthetized;

(b) the electroencephalogram can be monitored and changes in pattern with minor noxious stimuli may be a valuable guide. Thus, many experiments can be conducted while the EEG is in the unaroused state characteristic of moderate anaesthesia. However, some anaesthetics (e.g. chloralose) induce an EEG that cannot readily be interpreted, and the relation between EEG waveform and the suffering of pain is, in any case, not known. It should also be noted that changes in arterial PCO2 and the administration of atropine and certain other drugs may alter the relation between the EEG and behavioural state;

(c) the state of the pupil can provide a further indication of the level of anaesthesia. Generally, under anaesthesia pupils are constricted, and dilated pupils, or pupils which react rapidly to stimuli, are indicative of inadequate anaesthesia. This is not a suitable test for experiments on the visual system when drugs have been administered which paralyse accommodation and dilate the pupils.

(3) Nitrous oxide (N2O) has effective mood changing (tranquillizing) and analgesic properties and is useful because of the ease and consistency of delivery but, even at the maximum concentration feasible at normal pressures, it is not an adequate anaesthetic for surgery in cats. Caution should be used in relying upon it for maintenance, even when precautions have been taken to avoid noxious stimuli. It becomes especially important to assess the animal’s state periodically and to use supplementary agents as required.’

3. Human experiments

The Editorial Board is concerned that all work published in Experimental Physiology should have been conducted according to the highest standards of safety and ethics. Legislation and accepted practice concerning human experimentation vary from country to country and consequently it is difficult to define absolute requirements. However, work with human subjects should conform to the standards set by the Declaration of Helsinki (last modified in 2004), http://www.wma.net/e/policy/b3.htm, the Medical Research Council’s online guidelines MRC interim guidance on ethics of research involving human material derived from the nervous system (2003)' (http://www.mrc.ac.uk/pdf-nervous_tissue_guidance.pdf) and the guidelines set out below. The objectives must be to ensure that all risks are minimized and that subjects are not injured and do not feel they have been abused as a result of participating in the study. Any definition of abuse will include excessive or unexpected pain or discomfort experienced during the experiment. Note, in the case of experiments involving minors, any risks must have been considered absent or minimal, and evidence must be presented that the experiments were performed with the understanding and consent of the legal guardian.

All manuscripts must contain statements indicating that informed consent has been obtained, preferably in writing, studies have been performed according to the Declaration of Helsinki, and the procedures have been approved by the local ethics committee.

(1) The acceptability of procedures used will depend on the age and health of the subjects. Manuscripts should state the age, sex, health status and, where necessary, fitness of participants.

(2) ‘Informed’ consent means that subjects have been told not only of the procedures and risks from the experiment but also that they are free to withdraw at any time without jeopardy. Experiments with children must have, in addition to the acquiescence of the child, the informed consent of the parent or guardian.

(3) Experiments must be conducted by suitably qualified personnel with medical support where appropriate. The possible adverse physical and psychological effects of invasive procedures, painful stimuli, the stress of physical performance, sleeplessness, confinement or sensory deprivation must be borne in mind.

(4) Monetary or other rewards are commonly provided in physiological studies that involve discomfort. Such rewards should not be so large as to induce subjects to participate against their better judgement. Particular care should be taken to ensure that students and junior laboratory personnel are not inadvertently coerced to participate by senior staff.

(5) When drugs are to be given to a subject, their usual actions and potential side-effects must be explained verbally, and, when appropriate, in writing.

(6) It is the duty of the experimenter to minimize the physical risks to the subject. Such precautions will depend on the type of experiment: examples include having stops on mechanical devices, limiting the electric current provided by nerve stimulators and providing resuscitation facilities where necessary. Where procedures involve the sampling of body fluids suitable aseptic conditions must be used.

(7) Procedures involving exposure to radiation should be detailed separately in the manuscript and include a statement of the dose given.

(8) The identity of subjects must remain confidential; only with the written consent of the subject may his or her name be revealed.

(9) Before human biopsy or post-mortem tissue is taken for study, consent must be obtained from the subject, or relatives where appropriate. This should be stated in the manuscript.

Copyright and reproduction

Authors may make copies of their own papers published in Experimental Physiology, provided that such copies are for free distribution only; they must not be sold.

Authors may re-use their own illustrations in other publications appearing under their own name, without seeking permission, provided that the source of the material is properly acknowledged. Permission to reproduce material from Experimental Physiology, either in Experimental Physiology or in other publications, will not generally be given to third parties except with the consent of the authors concerned.

Specific permission will not be required for photocopying copyright material in the following circumstances.

1. For private study, provided the copying is done by the person requiring its use, or by an employee of the institution to which he/she belongs, without charge beyond the actual cost of copying.

2. For the production of multiple copies of such material, to be used for bona fide educational purposes, provided this is done by a member of the staff of the university, school or other comparable institution, for distribution without profit to student members of that institution, and provided the copy is made from the original journal. For all other matters relating to the reproduction of copyright material written application must be made to:

Blackwell Publishing Ltd, 9600 Garsington Road, Oxford OX4 2DQ, UK. Tel: +44 (0)1865 776868 Fax: +44 (0)1865 714591

PUBLICATION COSTS

Experimental Physiology does not impose submission or page charges.

1. Open access charges
Experimental Physiology is free to all readers 12 months after publication. However, authors can make their paper immediately freely available through Blackwell Publishing’s Online Open authors pay-to-publish service:
http://www.blackwellpublishing.com/static/onlineopen.asp

For information about funding agency policies on public access to scientific research and The Physiological Society's policy on public access, see: http://www.physoc.org/publications/publicaccess/ and http://www.physoc.org/publications/wellcomenih/

2. Colour charges
There is no charge for colour figures online. Authors are asked to contribute towards the cost of printing colour figures. Per figure charges are given at the end of the publisher’s colour work agreement form: http://www.blackwellpublishing.com/pdf/SN_Sub2000_F_CoW.pdf

The total cost will be: cost of colour print figures + mandatory UK VAT at 17.5%.

3. Offprint charges
Authors are supplied with a PDF file of the final published article, along with guidelines for its use. Offprints can be purchased from the publisher by completing the Offprints order form provided with the proof. For further information contact Blackwell Publishing Ltd: EPH{at}oxon.blackwellpublishing.com

ADMINISTRATIVE PROCEDURES

Submissions

All manuscripts must be submitted electronically using our online submission form (http://submit.expphysiol.org). Full instructions are given with the form. To avoid excessively large files, which are time consuming for both uploading by the authors and downloading for the reviewing process, no file should be larger than 5 MB.

Enquiries should be sent to:

Experimental Physiology
The Publications Office
PO Box 502
Cambridge
CB1 0AL, UK

Tel: + 44 (0)1223 400183
Fax: + 44 (0)1223 246858
Email:ephjournal{at}physoc.org
Web: http://ep.physoc.org

Manuscripts should be submitted as Microsoft Word files. These will be converted automatically into PDF files and it will be the responsibility of authors to check these PDF files to ensure that the conversion was successful. LaTeX files are not acceptable. As papers will be published online in manuscript form upon acceptance, it is important that figures are of a suitable quality at this stage. Full details of file formats are available at http://www.blackwellpublishing.com/bauthor/illustration.asp

A signed Exclusive Licence Form will be required upon submission together with any necessary permissions and if the manuscript contains any colour figures a Colour Work Agreement Form. Both forms are available in the Author Area of the online submission system.

Correspondence

Following submission of a manuscript, all correspondence will be dealt with by the relevant Editor via the Publications Office.

The Editors cannot accept responsibility for damage to or loss of papers submitted to them. Contributors are advised to keep copies of the typescript and illustrations.

Date of receipt

The date of receipt of each paper will be printed and is normally the date on which the manuscript is first received in the Publications Office. Papers submitted without all the information specified in these instructions will not be given editorial consideration until it has been provided; this applies especially to aspects of animal welfare/ethics. The date of receipt published will then refer to the date when a complete submission is received. If an author fails to deal with requested revisions within a reasonable time (usually 1 month) the date of original receipt will be replaced by the date on which the new version was received in the Publications Office.

Proofs

Proofs should be corrected and returned promptly since publication is in order of receipt of corrected proofs. Excessive alterations by the authors of the accepted copy may be subject to further editorial consideration and may be charged to the authors.

Offprints

The corresponding author is provided with a copy of the journal and a PDF file of their paper free of charge. Offprints can be supplied if ordered at the same time as the proofs are returned. An order form will be sent to authors with the proofs.

PREPARATION OF MANUSCRIPTS

General information

English spelling (as in The Chambers Dictionary) and terminology should be used (e.g. colour, fibre, noradrenaline). Clarity of expression and conciseness will be taken into consideration.

Arrangement of papers

The usual format is:

1. Title page
2. Abstract
3. Introduction
4. Methods
5. Results
6. Discussion
7. References
8. Acknowledgements
9. Figures and legends
10. Tables

Papers deviating from the usual format can be considered for publication if there are obvious and compelling reasons for the variation. Small print may be used sparingly. Footnotes are not acceptable.

1. Title page

The title of the paper should be as informative as possible, but should also be concise. The animal species should normally appear in the title. The Editors will not accept a series of papers with the same main title, e.g. ‘Studies in . . . Part I’, ‘Studies in . . . Part II’. For abbreviations that are acceptable in the title go to http://ep.physoc.org/misc/abbreviationslist.pdf

A running title not exceeding 70 characters and spaces must be given for page headings

Three key words for use in the reviewing process should be provided.

The total number of words in the paper, excluding references and figure legends, should be added to the title page.

Authors should assign their paper to one of the Subject Areas from the scroll down in the online submission form at http://submit.expphysiol.org/ After publication the paper will appear in an online collection of papers in the same Subject Area category. Authors can request that their paper is assigned to other online collections in the letter accompanying their submission.

Authorship

The author submitting a manuscript must ensure that all authors listed are eligible for authorship. The Editorial Board endorses the general principles set out in Guidelines on Good Publication Practice produced by the Committee on Publication Ethics (COPE; http://www.publicationethics.org.uk/guidelines).

Addresses

Authors should provide the minimum address information consistent with clarity and should ensure that authors’ affiliations are clearly indicated.

2. Abstract

Each research paper must start with an Abstract not exceeding 5% of the length of the paper. It should consist of a single paragraph, not numbered subsections; text for the Abstract will appear in bold. References may not be cited. Since the Abstract may be used by abstracting journals, a limit of 250 words is recommended. It must not exceed 5% of the text (excluding references and figure legends), with an absolute maximum of one printed page.

3. Introduction

The Introduction should make the background and the object of the research clear, and be understandable to the non-specialist. Reference to the authors’ previous work is desirable only if it has a direct bearing on the subject of the paper; an extensive historical review is not appropriate.

4. Methods

Methods are described once only and do not appear in the legends to figures and tables. Details should be sufficient to allow the work to be repeated by others. Authors should note that to be acceptable for publication, experiments on living vertebrates or Octopus vulgaris should conform with the principles of UK legislation.

Ethical information

Start the Methods section with a paragraph headed Ethical approval. This paragraph must contain the following information:

1. The name of the national or local ethics committee that approved the project and the relevant regulations governing all the studies described in the paper.

2. If experiments were conducted on humans, confirmation that informed consent was obtained, preferably in writing, that the studies conformed to the standards set by the latest revision of the Declaration of Helsinki, and that the procedures were approved by a properly constituted ethics committee, which should be named.

When describing experimental protocols the following information must be provided:

1. The numbers of animals studied.

2. In accord with the earlier section ‘Ethical standards’, all details concerning anaesthesia, including:

a. Generic name of the agents, with dose and route of administration.
b. Route and frequency of any supplemental doses.
c. When neuromuscular blocking agents are used, the criteria used for giving supplemental doses. The Results section should give a summary of these doses.

3. Where relevant, the method of humane killing at the end of the experiment.

4. In studies of isolated tissues, including cell cultures, details of the methods by which these tissues were obtained, including the method of anaesthesia or killing.

Ethical information must be included for each manuscript. It is not sufficient to refer to previous publications for details, unless the paper is one of a series published in the same issue.

Where appropriate, lists of solutions, chemicals and equipment, and an explanation of data handling procedures may be given as separate headed paragraphs. The maker’s name should be given for all non-standard chemicals, apparatus and equipment. Materials known by a trade name, e.g. Perspex, have the initial letter as a capital. The Latin names as well as the common name of non-mammalian species should be given.

5. Results

Quantitative observations are often better presented graphically than in tables. Authors should ensure that their data are treated correctly, taking statistical advice if necessary. Analysis of variance (ANOVA), not t tests, should be used for multiple comparisons; parametric and non-parametric statistics should be used appropriately, and particular care should be taken over the expression of means and errors where data have been transformed onto a logarithmic scale. Standard deviations and standard errors of the means (as appropriate) should be given with not more than two significant figures; the form used, and the n value, should be stated. Tests of significance should be specified in full, e.g. Student’s paired t test. It is not usually necessary to present the individual results of a large number of repeated tests if the number of measurements is stated. Theory and inference must be clearly distinguished from what was observed, and should not be elaborated upon in this section.

6. Discussion

The Discussion which follows the statement of Results should be separate from it. The assumptions involved in making inferences from the experimental results should be stated. The Discussion should not merely recapitulate the Results. Authors should provide a succinct conclusion to their work.

In appropriate circumstances an Appendix or a Theory section may be accepted where, for example, it is necessary to derive mathematical results required in the paper.

7. References

The paper should conclude with a list of the papers and books cited in the text. Authors should avoid an excessive number of references. Normally about 50 should be adequate. The order of references is strictly alphabetical, regardless of chronology. The format for references to papers and books, and to chapters in books, is as follows:

Patel A & Smith FG (2000). Renal haemodynamic effects of B2 receptor agonist bradykinin and B2 antagonist HOE 140 in conscious lambs. Exp Physiol 85, 811–818.

Adrian ED (1932). The Mechanism of Nervous Action. Humphrey Milford, London.

Buchan AMJ, Bryant MG, Polak JM, Gregor M, Ghatei MA & Bloom SR (1981). Development of regulatory peptides in the human fetal intestine. In Gut Hormones, 2nd edn, ed. Bloom SR & Polak JM, pp. 119–124. Churchill Livingstone, Edinburgh.

Attention to punctuation is required. Use only established abbreviated journal titles. See PubMed journals database: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=journals

'To download the current references style for use with EndNote, Reference Manager, ProCite, BibTeX and RefWorks go to http://ep.physoc.org/misc/ExperimentalPhysiology.os

DOIs for articles in press

Many journals now publish articles online ahead of print. This initial posting to the web qualifies as publication and the citation of such articles should include the DOI (digital object identifier) if the article’s full publication details have not yet been assigned:

Lipp P, Egger M & Niggli E (2002). Spatial characteristics of sarcoplasmic reticulum Ca2+ release events triggered by L-type Ca2+ current and Na+ current in guinea-pig cardiac myocytes. J Physiol; DOI: 10.1113/jphysiol.2001.013382.

In the text, references should be made by giving the author and the year of publication in parentheses, e.g. (Lamb, 1986), except when the author’s name is part of the sentence, e.g. ‘Lamb (1986) showed that . . . ’. Where several references are given together they are in chronological order, separated by semicolons.

When a paper written by two authors is cited, both names are given; for three or more authors only the first name is given, followed by ‘et al.’. Unpublished material may be referred to sparingly in the text by giving the authors’ initials and names followed by ‘unpublished observations’ or ‘personal communication’; such citations should not appear in the list of references. Authors should confirm on their declaration that the wording of any reference to unpublished work is approved by the person concerned. References cited as being ‘in press’ must have been accepted for publication, and the name of the journal or publisher included in the reference list.

8. Acknowledgements

Acknowledgements should be the minimum consistent with courtesy. The wording of acknowledgements of scientific assistance or advice must have been seen and approved by the persons concerned. Authors must indicate the source of their funding.

9. Figures and legends

Each figure should be numbered and accompanied by a corresponding legend that makes it comprehensible without reference to the text,although undue repetition should be avoided. For detailed instructions on preparing figures/tables please see: http://ep.physoc.org/misc/iforafigs.shtml. For instructions on electronic file requirements please see: http://www.blackwellpublishing.com/bauthor/illustration.asp.

Authors may submit coloured illustrations whenever they enhance the scientific value of the paper. Before a manuscript can be accepted, authors must complete a Colour Work Agreement Form which gives information on the cost of colour reproduction.

Permissions: where figures from previous publications are used (even if these have been redrawn), it is the author's responsibility to obtain permission from the original journal and to include these with the submission. It is also the author’s responsibility to make sure that reproduced material has been acknowledged as requested by the copyright owner (even if written copyright is not required).

Authors are encouraged to submit a figure for possible use on the cover, although there is no guarantee that it will be selected. It need not necessarily appear in the paper but should be related to it. The figure must not have appeared or been submitted elsewhere.

10. Tables

Tables should be used sparingly. They should be referred to in the text by arabic numerals, e.g. Table 3. Each table should have its own self-explanatory title. The same information should not be presented in both tabular and graphical forms. For preparation of tables see guidelines for preparing figures and tables available on the web site http://ep.physoc.org/misc/iforafigs.shtml

Supplemental material

Experimental Physiology gives authors the opportunity to submit data files that are inappropriate or impractical to include in the printed version for publication online only as separate supplemental material. These data may substantially enhance the importance of the research and be of benefit to readers, but should not be essential for the understanding of the paper, i.e. the manuscript must be able to stand alone in print and online without the data. Authors are encouraged to include data such as videos, 3-D structures/images and any other supplemental data too large for print publication.

All supplemental material must be submitted with the original manuscript. Figure legends should follow their corresponding figure. Please put all supplemental material into a single file up to 10 MB.

Links to web sites may be included in manuscripts, but these links must terminate on a permanent data repository, such as those of the host platforms used by the journal. Links to private author's web pages/sites are not permitted.

Abbreviations

Authors should avoid abbreviations unless they are easily understood and help in reading the paper. Abbreviations should be defined when first introduced and are normally printed in upper-case letters without stops (a list of preferred abbreviations is available at http://ep.physoc.org/misc/abbreviationslist.pdf).

Symbols, units and mathematical notation

Recommended mathematical symbols and ways of printing them are given in Quantities, Units, and Symbols (1975), published by the Royal Society, London; this also includes a full discussion of the use of units. The SI system of units and index notation should be used, e.g. ml s1 rather than ml/s. Guidance for the use of SI units and conventions for the typeface of symbols can also be found at http://physics.nist.gov/cuu/Units/index.html

Certain traditional units that are still in common usage are also acceptable, for example:

length Å (SI unit nm)
pressure mmHg, Torr (SI unit kPa)
radioactivity Ci = Curie (SI unit Bq)
O2 uptake and CO2 elimination l min1 (SI unit mol s1)

Authors should ensure that consistency is maintained throughout the manuscript, including illustrations and tables.

Chemical and biological nomenclature

In general, the conventions in chemical nomenclature adopted by the Biochemical Society should be followed. These are described in the Biochemical Journal Instructions to Authors available online from http://www.BiochemJ.org

Names of species and genera should be in italics (or underlined). Names of muscles, bones etc. should be in roman type (i.e. not in italics).


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